Ciprofloxacin treatment does not influence course or relapse rate of reactive arthritis and anterior uveitis
✍ Scribed by Denis Wakefield; Peter McCluskey; Manju Verma; Karim Aziz; Barrie Gatus; Gregory Carr
- Book ID
- 101389426
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 106 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
Objective:
To assess the efficacy of ciprofloxacin in the treatment of reactive arthritis (rea) and anterior uveitis (au) in a double-blind, randomized, placebo-controlled trial.
Methods:
Seventy-two patients participated in this study, 56 with rea and 42 with au (26 patients had both rea and au). ciprofloxacin (750 mg twice a day) was administered for 12 months with a 12-month followup. end points of the study included time to disease relapse and measures of disease severity.
Results:
There was no difference between groups in time to disease relapse, joint inflammation, number of joints and enthesis involved in patients with rea, or signs and symptoms of au.
Conclusion:
Long-term treatment of rea and au with ciprofloxacin made no statistically significant difference to the natural history of these diseases or their severity.