๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Ciprofloxacin attachment to porous-coated titanium surfaces

โœ Scribed by D. S. Dunn; Professor Srini Raghavan; R. G. Volz

Publisher
Wiley (John Wiley & Sons)
Year
1994
Tongue
English
Weight
783 KB
Volume
5
Category
Article
ISSN
1045-4861

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โœฆ Synopsis

A simple and effective method for attaching ciprofloxacin HCl salt to the surface of porouscoated titanium based orthopedic materials was developed. The method utilizes the electrophoretic migration of both fine ciprofloxacin HCl particles and ciprofloxacin ions to deposit the antibiotic salt on a positively biased surface. The quantity of antibiotic deposited can be easily and effectively controlled by varying the time of deposition and applied voltage. In vifm tests have indicated that the antimicrobial activity of the treated surfaces is retained for a period of 5 days. The method allows a significant amount of antibiotic to be deposited and could theoretically be used to deliver antibiotics to the tissues surrounding prosthetic devices in order to prevent postoperative infections.

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