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Cinchona-modified Ru catalysts for enantioselective heterogeneous hydrogenation of aromatic ketones

✍ Scribed by He-yan Jiang; Hua Chen; Rui-xiang Li


Book ID
118427255
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
184 KB
Volume
11
Category
Article
ISSN
1566-7367

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Enantioselective synthesis of ethyl nipe
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Ethyl nicotinate was hydrogenated to ethyl nipecotinate in two steps. In the first step, the starting material was converted to the 1,4,5,6-tetrahydro derivative with PdrC and hydrogen in 76% yield. The hydrogenation of this intermediate was investigated with both unmodified and 10,11-dihydrocinchon