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Cimetidine interaction with liver microsomes in vitro and in vivo: Involvement of an activated complex with cytochrome P-450

✍ Scribed by J.Chris Jensen; Roland Gugler


Book ID
115778331
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
531 KB
Volume
34
Category
Article
ISSN
0006-2952

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## Abstract Studies on the binding spectra of certain alkaloids with rat liver microsomes revealed that brucine, scopolamine and strychnine are type I compounds, whereas boldine, emetine, nicotine, reserpine and sanguinarine show type II binding. In contrast, colchicine and solanine failed to produ