Cimetidine inhibits angiogenesis and suppresses tumor growth
β Scribed by Takeshi Natori; Masataka Sata; Ryozo Nagai; Masatoshi Makuuchi
- Book ID
- 116313465
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 745 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0753-3322
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Nitroxyl (HNO) can inhibit the glycolytic enzyme glyceraldehyde 3βphosphate dehydrogenase (GAPDH). Because of the importance of glycolysis in many malignant cells, we thus propose that HNO can adversely affect tumor growth. This hypothesis was tested using __in vitro__ and __in vivo__ m
## Abstract Disturbances of the ratio between angiogenic inducers and inhibitors in tumor microenvironment are the driving force behind angiogenic switch critical for tumor progression. Angiogenic inhibitors may vary depending on organismal age and the tissue of origin. We showed that Ξ±~1~βantitryp