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Cimetidine impairs the elimination of chlormethiazole

โœ Scribed by G. Shaw; R. W. Bury; M. L. Mashford; K. J. Breen; P. V. Desmond


Publisher
Springer
Year
1981
Tongue
English
Weight
306 KB
Volume
21
Category
Article
ISSN
0031-6970

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The effect of placebo or cimetidine at a dose of 1 g daily on theophylline elimination was studied in a double-blind control manner in twelve healthy adult males aged 19-31 years. In a group of six, placebo had no effect on any of theophylline half-life (tb), volume of distribution ( v d ) , and tot