Cimetidine impairs the elimination of chlormethiazole
โ Scribed by G. Shaw; R. W. Bury; M. L. Mashford; K. J. Breen; P. V. Desmond
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 306 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Both cimetidine therapy and cirrhosis individually interfere with normal elimination of various drugs. Cimetidine is often prescribed in patients with cirrhosis but there is incomplete data on its effect on drug elimination in cirrhotics. The purpose of this study was to address this issue. Eight st
The disposition of theophylline was studied on four occasions in eight healthy adult males. The control mean theophylline half-life and clearance were 7.32 h and 086 ml min-Ikg-', respectively. After 5 days pretreatment with placebo the corresponding values of 7.01 and 0-88 were not significantly di
The effect of placebo or cimetidine at a dose of 1 g daily on theophylline elimination was studied in a double-blind control manner in twelve healthy adult males aged 19-31 years. In a group of six, placebo had no effect on any of theophylline half-life (tb), volume of distribution ( v d ) , and tot