✦ LIBER ✦

Cilobamine in the treatment of atypical depression

✍ Scribed by Steven Wager; Frederic Quitkin; Jonathan Stewart; Patrick McGrath; Wilma Harrison; Jeffrey Markowitz; Elaine Tricamo

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 444 KB
Volume: 3
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470030308

No coin nor oath required. For personal study only.

✦ Synopsis

Sixteen patients meeting our criteria for atypical depression were treated in a 7-week single-blind pilot study with cilobamine mesylate, an investigational antidepressant structurally distinct from tricyclic antidepressants (TCA) and monoamine oxidase inhibitors (MAOI). Nine patients (56 per cent) responded to cilobamine. Cilobamine patients were compared with a group of similar patients receiving placebo for 6 weeks in a separate double-blind study. The response rate to cilobamine was superior to that of placebo. Cilobamine patients also showed significantly greater improvement in Hamilton Depression Scale scores than did placebo patients. Previous studies have demonstrated the efficacy of MAOIs in atypical depression. This study suggests that certain antidepressants which are not MAOIs, and are free of dietary restrictions and the risk of hypertensive crises, may also be effective in atypical depression.

KEY wORDs-CilObamine, atypical depression, antidepressants.

📜 SIMILAR VOLUMES

Treatment of depressive mood in schizoph

Treatment of depressive mood in schizophrenia with the atypical antipsychotic quetiapine

✍ Hani Raoul Khouzam 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 48 KB 👁 2 views

Two patients with schizophrenia and depressive mood experienced remission in both their psychotic and depressive symptoms during treatment with the atypical antipsychotic quetiapine. These case reports illustrate the antipsychotic clinical efficacy of quetiapine and its antidepressant effects in the

Frequency of atypical depression in late

Frequency of atypical depression in late-life depressed outpatients

✍ Franco Benazzi 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 62 KB

An open trial of venlafaxine for the tre

An open trial of venlafaxine for the treatment of late-life atypical depression

✍ Steven P. Roose; Marissa Miyazaki; Dev Devanand; Stuart Seidman; Linda Fitzsimmo 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 79 KB 👁 1 views

## Abstract ## Objectives The atypical subtype in patients with major depressive disorder is characterized by mood reactivity, significant weight gain or increase in appetite, hypersomnia, leaden paralysis and a long‐standing pattern of interpersonal rejection sensitivity. Though atypical depressi

A double-blind placebo-controlled compar

A double-blind placebo-controlled comparison of phenelzine and imipramine in the treatment of bulimia in atypical depressives

✍ Rothschild, Rachel ;Quitkin, H. Matthew ;Quitkin, Frederic M. ;Stewart, Jonathan 📂 Article 📅 1994 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 606 KB

Treatment resistant depression in the el

Treatment resistant depression in the elderly

✍ Dr Deirdre Bonner; Robert Howard 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 464 KB 👁 1 views

The Place of Milnacipran in the Treatmen

The Place of Milnacipran in the Treatment of Depression

✍ S. Kasper 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 109 KB 👁 2 views

Modern community-based studies have revealed high prevalence rates for major depression in adults. Despite this high prevalence, many depressed individuals do not seek treatment and only a minority of those that do are prescribed antidepressants. This paper considers the role of antidepressants, esp