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Ciliary neurotrophic factor promotes the regrowth capacity but not the survival of intraorbitally axotomized retinal ganglion cells in adult hamsters

โœ Scribed by K.S Cho; P.M Chan; K.-F So; H.K Yip; S.K Chung

Book ID
117493143
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
326 KB
Volume
94
Category
Article
ISSN
0306-4522

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โœ Yan, Qiao ;Wang, Jue ;Matheson, Christine R. ;Urich, Janal L. ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 842 KB

Adult rat retinal ganglion cells (RGC) undergo degeneration after optic nerve transection. Studies have shown that exogenously applied neurotrophic factors such as brain-derived neurotrophic factor (BDNF) can attenuate axotomy-induced as well as developmental RGC death. Here, we examined whether gli