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Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

✍ Scribed by Sendtner, M.; Schmalbruch, H.; Stöckli, K. A.; Carroll, P.; Kreutzberg, G. W.; Thoenen, H.

Book ID
109781349
Publisher
Nature Publishing Group
Year
1992
Tongue
English
Weight
415 KB
Volume
358
Category
Article
ISSN
0028-0836

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We investigated the histological effects of ciliary neurotrophic factor on degenerating motor neurons, their axons, and skeletal muscles in 68 wobbler mice with motor neuron disease. Treatment consisted of recombinant rat or human ciliary neurotrophic factor (or a vehicle solution), 1-mg/kg subcutan