Ciliary Function in Mammalian Development

✍ Scribed by Bradley K. Yoder (Eds.)

• Publisher: Academic Press
• Year: 2008
• Tongue: English
• Leaves: 469
• Series: Current Topics in Developmental Biology 85
• Edition: 1
• Category: Library

✦ Synopsis

Cilia-the tiny hair-like structures on the surface of cells-have recently been identified as playing a role in a variety of disease and developmental disorders. Absent or defective cilia in certain cells can cause infertility, blindness, kidney disease, and lung disease. This volume presents recent findings in cilia research and current thought on the role of cilia in disease and developmental abnormalities.

✦ Table of Contents

Content:
Series Editors
Page ii

Copyright Page
Page iv

Contributors to Volume 85
Pages xi-xiii

Preface
Pages xv-xix
Bradley K. Yoder

Chapter 1 Basal Bodies: Platforms for Building Cilia Review Article
Pages 1-22
Wallace F. Marshall

Chapter Two Intraflagellar Transport (IFT): Role in Ciliary Assembly, Resorption and Signalling Review Article
Pages 23-61
Lotte B. Pedersen, Joel L. Rosenbaum

Chapter 3 How Did the Cilium Evolve? Review Article
Pages 63-82
Peter Satir, David R. Mitchell, Gáspár Jékely

Chapter 4 Ciliary Tubulin and Its Post-Translational Modifications Review Article
Pages 83-113
Jacek Gaertig, Dorota Wloga

Chapter 5 Targeting Proteins to the Ciliary Membrane Review Article
Pages 115-149
Gregory J. Pazour, Robert A. Bloodgood

Chapter Six Cilia: Multifunctional Organelles at the Center of Vertebrate Left–Right Asymmetry Review Article
Pages 151-174
Basudha Basu, Martina Brueckner

Chapter 7 Ciliary Function and Wnt Signal Modulation Review Article
Pages 175-195
Jantje M. Gerdes, Nicholas Katsanis

Chapter Eight Primary Cilia in Planar Cell Polarity Regulation of the Inner Ear Review Article
Pages 197-224
Chonnettia Jones, Ping Chen

Chapter 9 The Primary Cilium: At the Crossroads of Mammalian Hedgehog Signaling Review Article
Pages 225-260
Sunny Y. Wong, Jeremy F. Reiter

Chapter 10 The Primary Cilium Coordinates Signaling Pathways in Cell Cycle Control and Migration During Development and Tissue Repair Review Article
Pages 261-301
Søren T. Christensen, Stine F. Pedersen, Peter Satir, Iben R. Veland, Linda Schneider

Chapter 11 Cilia Involvement in Patterning and Maintenance of the Skeleton Review Article
Pages 303-332
Courtney J. Haycraft, Rosa Serra

Chapter 12 Olfactory Cilia: Our Direct Neuronal Connection to the External World Review Article
Pages 333-370
Dyke P. McEwen, Paul M. Jenkins, Jeffrey R. Martens

Chapter 13 Ciliary Dysfunction in Developmental Abnormalities and Diseases Review Article
Pages 371-427
Neeraj Sharma, Nicolas F. Berbari, Bradley K. Yoder

Index
Pages 429-436

Contents of Previous Volumes
Pages 437-464