Volume 1
Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis.
Volume 2
Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data.
This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored.
Content:
Chapter 1 The Lysosome Concept (pages 1โ35): Christian de Duve
Chapter 2 Lysosomes in the Physiology and Pathology of Cells: Contributions of Staining Methods (pages 36โ77): Alex B. Novikoff
Chapter 3 Lysosomes: Distribution in Animals, Hydrolytic Capacity and Other Properties (pages 78โ113): A. L. Tappel, P. L. Sawant and S. Shibko
Chapter 4 Some Observations on the Occurrence and Nature of Esterases in Lysosomes (pages 114โ125): S. J. Holt
Chapter 5 The Cytoplasmic Granules of Phagocytic Cells and the Degradation of Bacteria (pages 126โ150): Zanvil A. Cohn, James G. Hirsch and Edith Wiener
Chapter 6 Dynamics of Adrenal Function in Man (pages 151โ175): Peter H. Forsham, Vincent Di Raimondo, Donald Island, Arthur P. Rinfret and Richard H. Orr
Chapter 7 Influence of the Injection of Triton Wr?1339 On the Properties of Rat?Liver Lysosomes (pages 176โ200): R. Wattiaux, M. Wibo and P. Baudhuin
Chapter 8 Fine Structure and Enzymic Activity of Protozoan Food Vacuoles (pages 201โ225): M. Muller, P. Rohlich, J. Toth and I. Toro
Chapter 9 The Relation to Lysosomes of the In Vivo Metachromatic Granules (pages 226โ263): A. M. Dalcq
Chapter 10 Properties and Role of Acid Hydrolases of the Mullerian Ducts During Sexual Differentiation in the Male Chick Embryo (pages 264โ281): Denise Scheib
Chapter 11 Behaviour and Properties of Acid Hydrolases in Regressing Tails of Tadpoles During Spontaneous and Induced Metamorphosis In Vitro (pages 282โ310): Rudolf Weber
Chapter 12 Lysosomal Changes During Liver Injury and Mammary Involution (pages 311โ335): T. F. Slater, A. L. Greenbaum and D. Y. Wang
Chapter 13 Lysosome Changes in Liver Injury (pages 335โ361): Mario Umberto Dianzani
Chapter 14 The Reversible Activation of Lysosomes in Normal Cells and the Effects of Pathological Conditions (pages 362โ383): Lucille Bitensky
Chapter 15 Action of Vitamin A on the Stability of Lysosomes In Vivo and In Vitro (pages 384โ404): J. T. Dingle