Volume 1
Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis.
Volume 2
Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data.
This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored.
Content:
Chapter 1 Chairman's Opening Remarks (pages 1โ2): C. E. Dent
Chapter 2 Structure of Bone from the Anatomical to the Molecular Level (pages 3โ13): Arne Engstrom
Chapter 3 Structure of Bone Salts (pages 14โ35): Marcel J. Dallemagne and Claudine Fabry
Chapter 4 The Histological Remodelling of Adult Bone: An Autoradiographic Study (pages 36โ46): P. Lacroix
Chapter 5 Fibrogenesis and the Formation of Matrix in Developing Bone (pages 47โ64): S. Fitton Jackson and J. T. Randall
Chapter 6 The Mucopolysaccharides of Bone (pages 65โ74): Karl Meyer
Chapter 7 Autoradiographic Studies of the Formation of the Organic Matrix of Cartilage, Bone and the Tissues of Teeth (pages 75โ88): Leonard F. Blanger
Chapter 8 Uptake of 35S in the Differentiation and Growth of Cartilage and Bone (pages 89โ102): Rodolfo Amprino
Chapter 9 In vitro Uptake and Exchange of Bone Citrate (pages 103โ116): W. D. Armstrong and Leon Singer
Chapter 10 The Magnesium Content of Bone in Hypomagnesaemic Disordersof Livestock (pages 117โ134): K. I. Blaxter
Chapter 11 The Mechanism of Nutrition in Bone and How it Affects its Structure, Repair and Fate on Transplantation (pages 135โ147): W. R. Harris and A. W. Ham
Chapter 12 Studies on the Repair of Fractures Using 32P (pages 148โ160): Pierre H. Cartier, Benedetto de Berkard and Jean Lagrange
Chapter 13 Metabolic Studies on Vitamin D (pages 161โ174): E. Kodicek
Chapter 14 The Mode of Action of Vitamin D (pages 175โ186): R. Nicolaysen and N. Eeg?Larsen
Chapter 15 Variations in Sensitivity to Vitamin D: From Vitamin D Resistant Rickets, Vitamin D Avitaminotic Rickets and Hypervitaminosis D to Idiopathic Hypercalcaemia (pages 187โ205): G. Fanconi
Chapter 16 Present Knowledge of Parathyroid Function, with Especial Emphasis upon its Limitations (pages 206โ221): J. E. Howard
Chapter 17 The Indirect Assessment of Parathyroid Function (pages 222โ238): B. E. C. Nordin and Russell Fraser
Chapter 18 Vascularity of Bone in Relation to Pathological Studies: (Paget's Disease; Sudeck's Atrophy; Osteoarthritis of the Hip) (pages 239โ248): E. Rutishauser
Chapter 19 Some Observations on Experimental Bone Disease (pages 249โ257): Richard H. Follis
Chapter 20 Osteodysmetamorphosis Foetalis a Newly Discovered Characteristic Skeletal Disease Showing Low Serum and Tissue Alkaline Phosphatase Activity (Hypophosphatasia) (pages 258โ271): Bengt Engfeldt and Rolf Zetterstrom
Chapter 21 Bone as a Critical Organ for the Deposition of Radioactive Materials (pages 272โ292): Hermann Lisco