✦ LIBER ✦

CH/π hydrogen bonds as evidenced in the substrate specificity of acetylcholine esterase

✍ Scribed by Yoji Umezawa; Motohiro Nishio

Publisher: Wiley (John Wiley & Sons)
Year: 2005
Tongue: English
Weight: 362 KB
Volume: 79
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.20352

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✦ Synopsis

Abstract

The crystal structure of acetylcholine esterase (AchE) in complex with various inhibitors, investigated as drugs for improvement of the cognitive ability of early stage Alzheimer's disease, has been analyzed with the use of our program CHPI. A number of CH/π hydrogen bonds have been disclosed in the binding of the inhibitors with Torpedo californica AchE. It has been demonstrated that, in order to be effective in the binding with AchE, C—H bonds in the inhibitor need not be polarized. © 2005 Wiley Periodicals, Inc. Biopolymers 79: 248–258, 2005

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at [email protected]

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