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Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters

✍ Scribed by Koji Komeda; Shinji Takai; Denan Jin; Keitaro Tashiro; Michihiro Hayashi; Nobuhiko Tanigawa; Mizuo Miyazaki

Book ID: 118088293
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 569 KB
Volume: 40
Category: Article
ISSN: 1386-6346
DOI: 10.1111/j.1872-034x.2010.00672.x

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## Abstract ## Background The interaction between fibrogenic cells and extracellular matrix plays a role in liver fibrosis, yet the mechanisms are largely unknown. Secreted protein, acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that is expressed by hepatic stellate cells and