Chronotropic and cyclic adenosine monophosphate response of fetal rat heart in organ culture to isoproterenol, quinidine, and a dysrhythmogenic agent
✍ Scribed by Charles L. Eyer; William E. Johnson
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 566 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
The fetal rat heart in organ culture was used to investigate rate chanes by various cardioactive agents. Concomitantly, the effect of these pharmacologically induced rate changes on steady-state cyclic adenosine monophosphate levels was determined. Isoproterenol increased the fetal rat heart rate and cyclic adenosine monophosphate in a concentration-related fashion. Quinidine produced a concentration-related decrease in heart rate and no change in cyclic adenosine monophosphate level. The dysrhythmogenic agent produced concentration-related negative chronotropism in the fetal rat heart preparation and significant elevations in cyclic adenosine monophosphate at concentrations without chronotropic action. No correlation between chronotropic effect of a drug and cyclic adenosine monophosphate levels was observed.