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Chronic verapamil administration alters phenytoin pharmacokinetics in the rat

โœ Scribed by M.O.M. Tanira; I.A. Wasfi; A.K. Bashir; D.W.G. Harron

Book ID
113366639
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
225 KB
Volume
102
Category
Article
ISSN
0378-5173

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Verapamil is a chiral calcium channel blocking drug which is useful clinically as the racemate in treating hypertension and arrhythmia. The published pharmacokinetic data for verapamil enantiomers in the rat model are limited. Utilizing a stereospeciยฎc highperformance liquid chromatographic (HPLC) a