Chronic rejection and chronic cyclosporin toxicity in renal allografts

✍ Scribed by Manuel Pascual; Rita D Swinford; Julie R Ingelfinger; Winfred W Williams; A.Benedict Cosimi; Nina Tolkoff-Rubin

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 172 KB
• Volume: 19
• Category: Article
• ISSN: 0167-5699
• DOI: 10.1016/s0167-5699(98)01324-3

✦ Synopsis

Recent evidence indicates that growth factors are critically important in both chronic rejection and chronic cyclosporin A toxicity, suggesting that these two entities share a common pathophysiological pathway, leading to progressive allograft failure. Here, Manuel Pascual and colleagues discuss the relevance of growth factors to chronic allograft nephropathy, and the implications for therapy in view of the great choice of immunosuppressive drugs now available.