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Chronic progesterone treatment of male rats with unilateral 6-hydroxydopamine lesion of the dorsal striatum exasperates parkinsonian symptoms

✍ Scribed by O.Y. Chao; J.P. Huston; A. von Bothmer; M.E. Pum

Book ID: 116789518
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 677 KB
Volume: 196
Category: Article
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2011.08.043

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## Abstract This study was designed to test whether chronic treatment with the metabotropic glutamate receptor 5 (mGlu5R) antagonist MPEP showed antiparkinsonian effects in rats unilaterally lesioned with 6‐hydroxydopamine (6‐OHDA) (a “classic” model of Parkinson's disease, PD), and to evaluate whe