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Chronic potentiation of cardiac L-type Ca2+ channels by pirfenidone

✍ Scribed by Ramos-Mondragon, R.; Galindo, C. A.; Garcia-Castaneda, M.; Sanchez-Vargas, J. L.; Vega, A. V.; Gomez-Viquez, N. L.; Avila, G.

Book ID
118188552
Publisher
Oxford University Press
Year
2012
Tongue
English
Weight
887 KB
Volume
96
Category
Article
ISSN
0008-6363

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✍ FranΓ§ois Tiaho; JoΓ«l Nargeot; Sylvain Richard πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 753 KB

The beta-adrenergic cascade is important for the regulation of voltage-dependent Ca channels by phosphorylation. Here we report that isoproterenol (ISO) profoundly alters the voltage-dependent properties of L-type Ca channels studied in rat ventricular cells. ISO (1 microM) shifted both threshold an