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Chronic phencyclidine, like amphetamine, produces a decrease in [3H]spiroperidol binding in rat striatum

โœ Scribed by Harold A. Robertson

Book ID
115876979
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
220 KB
Volume
78
Category
Article
ISSN
0014-2999

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Reduction of3H-spiroperidol binding in r
Reduction of3H-spiroperidol binding in rat striatum and frontal cortex by chronic amphetamine: Dose response, time course and role of sustained dopamine release
โœ E. B. Nielsen; M. Nielsen; C. Braestrup ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› Springer ๐ŸŒ English โš– 552 KB

After 5 days of continuous treatment with d-amphetamine base in doses greater than 0.5 mg/kg/h maintained by subcutaneously implanted osmotic minipumps, specific binding of 3H-spiroperidol was reduced in rat striatum and frontal cortex as previously reported. These effects were dose-dependent at low