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Chronic Opiate Administration: Demonstration of Tolerance in an Invertebrate

โœ Scribed by IVETTE BERRIOS; MICHAEL K. LEUNG; GEORGE B. STEFANO

Book ID
119859597
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
113 KB
Volume
494
Category
Article
ISSN
0890-6564

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Functional MRI (fMRI) was employed to determine whether repeated heroin self-administration (SA) produces tolerance or sensitization in the brain of heroin-SA rats. Twelve rats were evenly divided into saline and heroin (0.06 mg/kg, 4 hr/day) SA groups. There was a progressive increase in drug-SA be