Chronic nicotine administration incrreases binding of [3H]Domperidone in rat nucleus accumbens
✍ Scribed by M. A. Reilly; E. P. Lapin; H. S. Maker; A. Lajtha
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 488 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0360-4012
No coin nor oath required. For personal study only.
✦ Synopsis
An apparent inverse relationship between smoking and Parkinson's disease prompted an investigation of the effect of chronic nicotine administration on dopaminergic and serotonergic receptors in rat brain. Nicotine, 0.8 mg/kg, was injected once daily, five times per week, for 6 weeks. In nucleus accumbens the Kd for [3H]domperidone was increased 2-4-fold, and the Bmax was increased 1.5-2-fold. No changes were observed in the binding of [3H]domperidone in caudate-putamen or in that of [3H]ketanserin in frontal cortex. It is concluded that chronic nicotine administration may have a suppressant effect on central nervous system release of dopamine that in pre-parkinsonian persons causes an aversion to the effects of smoking.