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Chronic myeloid leukemia: Pathophysiology, diagnostic parameters, and current treatment concepts

✍ Scribed by Christian Sillaber; Matthias Mayerhofer; Hermine Agis; Verena Sagaster; Christine Mannhalter; Wolfgang R. Sperr; Klaus Geissler; Peter Valent

Publisher: Springer Vienna
Year: 2003
Tongue: English
Weight: 336 KB
Volume: 115
Category: Article
ISSN: 0043-5325
DOI: 10.1007/bf03041033

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## Abstract Treatments for chronic myeloid leukemia (CML) represent a success story in molecular medicine. The development of imatinib, a tyrosine kinase inhibitor (TKI) targeted against the causative Bcr‐Abl oncoprotein in CML, has resulted in hematologic and cytogenetic remissions in all phases o