## Abstract Age‐related cognitive decline is one of the major aspects that impede successful aging in humans. Environmental factors, such as chronic stress, can accelerate or aggravate cognitive deficits during aging. While there is abundant evidence that chronic stress directly affects cognitive p
✦ LIBER ✦
Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation
✍ Scribed by Mar Cuadrado-Tejedor; Ana Ricobaraza; Joaquín Del Río; Diana Frechilla; Rafael Franco; Alberto Pérez-Mediavilla; Ana Garcia-Osta
- Book ID
- 116286230
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 680 KB
- Volume
- 220
- Category
- Article
- ISSN
- 0166-4328
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## Abstract Alzheimer's disease (AD) is the most prevalent form of dementia among the elderly. Although the underlying cause has yet to be established, numerous data have shown that oxidative stress is implicated in AD as well as in preclinical stages of AD, such as mild cognitive impairment (MCI).