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Chronic methylphenidate alters locomotor activity and dopamine transporters differently from cocaine

✍ Scribed by Sari Izenwasser; Abigail E Coy; Bruce Ladenheim; Richard J Loeloff; Jean Lud Cadet; Dawn French

Book ID
114017224
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
231 KB
Volume
373
Category
Article
ISSN
0014-2999

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The aim of this study was to examine the effects of serotonergic lesions to the dorsal raphe on midbrain dopaminergic systems. 5,7-Dihydroxytryptamine lesions of the dorsal raphe resulted in a substantial loss of serotonin in the medial prefrontal cortex (about 75%) and the nucleus accumbens (about