Written by over 50 internationally distinguished experts, 30 more than the first edition, and contains nine new chapters! Continuing in the esteemed tradition and heralded success of the first edition, Chronic Lymphoid Leukemias, Second Edition offers a full overview of chronic lymphocytic leukemia (CLL) from multiple perspectives-covering all major developments since the previous edition was published eight years ago. Chronicling the complete history and variations of CLL-type leukemia, the Second Edition ยทreviews the origin, nature, and molecular differences between B-CLL and T-CLL/PLL leukemias ยทanalyzes core constituents of apoptosis and causes for dysregulation of programmed cell death (PCD) in B-CLL ยทexamines recent research on the role cytokines and regulatory molecules may play in cross-cell communication ยทprofiles commonly used vectors for somatic gene therapy, as well as the latest advances in genetic engineering and vector design and production ยทutilizes up-to-the-minute techniques such as fluorescence in-situ hybridization (FISH) and comparative genomic hybridization (CGH) to detect genetic abnormalities and aberrations ยทexplores current measures of supportive care with splenectomy, cytokine proteins, and intravenous immunoglobulin applications ยทidentifies how to manage infectious and psychiatric complications in patients with CLL ยทand much more! Provides contemporary results on the efficacy of nucleoside analog combinations such as ara-C with fludarabine and cladribine and on the emerging nucleosides nelarabine and clofarabine! Copiously supplemented with over 2500 literature references-1000 more than the first edition-Chronic Lymphoid Leukemias, Second Edition fulfills the reference needs of oncologists, hematologists, immunologists, pathologists, infectious disease specialists, internists, molecular biologists, and medical school students in these disciplines.