Chronic lymphocytic leukemia in Korean patients: frequent atypical immunophenotype and relatively aggressive clinical behavior

Enzymatic activity of circulating protea

Enzymatic activity of circulating proteasomes correlates with clinical behavior in patients with chronic lymphocytic leukemia

✍ Wanlong Ma; Hagop Kantarjian; Susan O'Brien; Iman Jilani; Xi Zhang; Zeev Estrov; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 217 KB

## Abstract ## BACKGROUND The ubiquitin‐proteasome pathway has been implicated in the pathogenesis of many hematologic malignancies. ## METHODS The authors measured proteasome peptidase activity levels in plasma samples from 225 patients with chronic lymphocytic leukemia (CLL) and correlated the