## Abstract Levodopa (L‐dopa) administered with a dopadecarboxylase inhibitor (DDI) increases homocysteine plasma levels. This may support the onset of atherosclerosis‐related disorders and neuropsychiatric complications in patients with Parkinson's disease (PD). This homocysteine elevation is cons
Chronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's disease
✍ Scribed by Siegfried Muhlack; Dirk Woitalla; Jacob Welnic; Svenja Twiehaus; Horst Przuntek; Thomas Müller
- Book ID
- 116766703
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 83 KB
- Volume
- 363
- Category
- Article
- ISSN
- 0304-3940
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📜 SIMILAR VOLUMES
## Abstract Levodopa, typically ingested chronically at high daily doses, is predictably methylated by means of a series of reactions using B vitamins, which convert methionine to homocysteine. Elevated total plasma homocysteine (tHcy), a risk factor for dementia, has been found in PD patients usin
## Abstract Homocysteine, cysteine, and cysteinyl‐glycine are all metabolically interrelated. Levodopa/decarboxylase inhibitor (LD/DCI) administration increases total homocysteine (tHcy) plasma levels. Objectives were to investigate associations between LD/DCI intake, concentrations of tHcy, cystei
## Abstract Dementia is a frequent non‐motor feature of Parkinson's disease (PD). Elevated plasma homocysteine (Hcy) levels have been associated with both cognitive impairment and dementia. Increased Hcy levels have been observed in levodopa‐treated patients with PD. The objective of our study was