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Chronic inhibition of glycogen synthase kinase-3 protects against rotenone-induced cell death in human neuron-like cells by increasing BDNF secretion

✍ Scribed by Alfredo Giménez-Cassina; Filip Lim; Javier Díaz-Nido

Book ID: 118488224
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 738 KB
Volume: 531
Category: Article
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2012.10.046

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re