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Chronic inflammatory responses to microgel-based implant coatings

✍ Scribed by Amanda W. Bridges; Rachel E. Whitmire; Neetu Singh; Kellie L. Templeman; Julia E. Babensee; L. Andrew Lyon; Andrés J. García

Book ID
102296849
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
349 KB
Volume
94A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

Inflammatory responses to implanted biomedical devices elicit a foreign body fibrotic reaction that limits device integration and performance in various biomedical applications. We examined chronic inflammatory responses to microgel conformal coatings consisting of thin films of poly(N‐isopropylacrylamide) hydrogel microparticles cross‐linked with poly(ethylene glycol) diacrylate deposited on poly(ethylene terephthalate) (PET). Unmodified and microgel‐coated PET disks were implanted subcutaneously in rats for 4 weeks and explants were analyzed by histology and immunohistochemistry. Microgel coatings reduced chronic inflammation and resulted in a more mature/organized fibrous capsule. Microgel‐coated samples exhibited 22% thinner fibrous capsules that contained 40% fewer cells compared to unmodified PET disks. Furthermore, microgel‐coated samples contained significantly higher levels of macrophages (80%) than unmodified PET controls. These results demonstrate that microgel coatings reduce chronic inflammation to implanted biomaterials. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010

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