Chronic imipramine treatment normalizes levels of tyrosine hydroxylase in the locus coeruleus of chronically stressed rats
β Scribed by Kathleen R. Melia; Eric J. Nestler; Ronald S. Duman
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 472 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0033-3158
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π SIMILAR VOLUMES
Tyrosine hydroxylase (TH) activity can be modified by changes in the specific activity of the enzyme (SA TH ) or in the levels of active enzyme. We developed a methodology making it possible to measure with excellent anatomical resolution TH enzymatic activity and TH protein quantity by quantitative
The neurophysiological effects of acute and chronic treatment with the tricyclic antidepressant drug imipramine were investigated. Brainstem (BAER) and middle latency (MLR) auditory evoked responses were monitored in the alert and immobile rat. Daily injection of imipramine (10 mg/kg, IP) for 2 week