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Chronic IL-1β-Mediated Neuroinflammation Mitigates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease without Inducing Overt Neurodegeneration

✍ Scribed by Matousek, Sarah B.; Ghosh, Simantini; Shaftel, Solomon S.; Kyrkanides, Stephanos; Olschowka, John A.; O’Banion, M. Kerry

Book ID
107381809
Publisher
Springer US
Year
2011
Tongue
English
Weight
547 KB
Volume
7
Category
Article
ISSN
1557-1890

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Background One of the pathological hallmarks of Alzheimer's disease (AD) is deposits of amyloid β-peptide (Aβ) in neuritic plaques and cerebral vessels. Immunization of AD mouse models with Aβ reduces Aβ deposits and improves memory and learning deficits. Because recent clinical trials of immunizati