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Chronic fluoxetine induces opposite changes in G protein coupling at pre and postsynaptic 5-HT1A receptors in rat brain

✍ Scribed by M. Elena Castro; Alvaro Diaz; Elena del Olmo; Angel Pazos


Book ID
117187525
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
231 KB
Volume
44
Category
Article
ISSN
0028-3908

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Flibanserin (BIMT 17) has been described as a 5-HT 1A agonist with preferential affinity for postsynaptic 5-HT 1A receptors and as a 5-HT 2A antagonist. Indeed, using the forskolin-stimulated cAMP accumulation technique, flibanserin but not the 5-HT 1A agonists buspirone and 8-OH-DPAT had agonistic