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Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons

✍ Scribed by Nam Sang Cheung; Chor Hui Vivien Koh; Boon Huat Bay; Robert Z Qi; Meng Shyan Choy; Qiu-Tian Li; Kim Ping Wong; Matthew Whiteman


Book ID
116287946
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
528 KB
Volume
315
Category
Article
ISSN
0006-291X

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Overstimulation of ionotropic glutamate receptors leads to excitotoxic neuronal death, which has been implicated in the neurodegeneration of neurological diseases. The present study examined the role of putative low-affinity kainate receptor subtype (GluR5-7) agonists in excitotoxicity in cultured m