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Chronic diazepam exposure decreases transcription of the rat GABAA receptor γ2-subunit gene

✍ Scribed by R.A Holt; I.L Martin; A.N Bateson


Book ID
117386900
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
183 KB
Volume
48
Category
Article
ISSN
0169-328X

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## Abstract Diazepam is widely prescribed as an anxiolytic but its therapeutic application is limited because with daily use tolerance develops to certain aspects of its pharmacological profile. We compared the effects of two dosing paradigms on GABA~A~ receptor gene expression and benzodiazepine b