Chronic arthritis of rabbits induced by mycoplasmas. III. Induction with nonviable mycoplasma arthritidis antigens

✍ Scribed by Leigh Rice Washburn; Barry C. Cole; John R. Ward

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 958 KB
• Volume: 25
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780250805

✦ Synopsis

Abstract

Preexposure of rabbits to Mycoplasma arthritidis predisposed them to subsequent development of chronic inflammation in knee joints challenged with nonviable M arthritidis antigens. Rabbits sensitized by hyperimmunization developed a more severe arthritis than those sensitized by infection. Unsensitized rabbits responded minimally to intraarticular injection of nonviable organisms. These results suggested that an immune response to a persisting mycoplasmal antigen might be capable of sustaining chronic inflammation in rabbits with arthritis induced by viable M arthritidis.