Chronic and single administration of pentylenetetrazol modifies benzodiazepine receptor-binding: an autoradiographic study

✍ Scribed by L. Rocha; R.F. Ackermann; J. Engel Jr.

• Book ID: 103932459
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 626 KB
• Volume: 24
• Category: Article
• ISSN: 0920-1211
• DOI: 10.1016/0920-1211(95)00104-2

✦ Synopsis

Benzodiazepine (BDZ) receptor-binding changes in the rat brain induced by pentylenetetrazol (PTZ) were investigated by in vitro autoradiography. Our experiments revealed that a single PTZ administration produced BDZ-binding decrease in cingulate, frontal, temporal, parietal and piriform cortices; caudate putamen; medial, basolateral and cortical amygdaloid nuclei; medial, ventromedial and ventroposterior thalamic nuclei; substantia nigra pars compacta and periaqueductal gray. Fully kindled rats with chronic PTZ treatment showed reduced BDZ receptor-binding in cingulate, frontal, parietal and piriform cortices; caudate putamen; medial, ventromedial and ventroposterior thalamic nuclei; and periaqueductal gray. These effects resulted from decrease in the binding capacity. Our results support that PTZ-induced chemical kindling may be associated with significant changes of the GABAergic systems and BDZ-binding from the first administration.