Chronic administration of valproic acid induces a decrease in rat striatal glutamate and taurine levels

Chronic but not acute intracerebroventri

Chronic but not acute intracerebroventricular administration of amyloid β-peptide(25–35) decreases somatostatin content, adenylate cyclase activity, somatostatin-induced inhibition of adenylate cyclase activity, and adenylate cyclase I levels in the rat hippocampus

✍ E. Burgos-Ramos; A. Hervás-Aguilar; L. Puebla-Jiménez; M.C. Boyano-Adánez; E. Ar 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 1 views

## Abstract Although alterations in adenylate cyclase (AC) activity and somatostatin (SRIF) receptor density have been reported in Alzheimer's disease, the effects of amyloid β‐peptide (Aβ) on these parameters in the hippocampus are unknown. Our aim was to investigate whether the peptide fragment A