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Chronic Administration of Ketamine Elicits Antidepressant-Like Effects in Rats without Affecting Hippocampal Brain-Derived Neurotrophic Factor Protein Levels

✍ Scribed by Lêda S. Garcia; Clarissa M. Comim; Samira S. Valvassori; Gislaine Z. Réus; Ana Cristina Andreazza; Laura Stertz; Gabriel R. Fries; Elaine Cristina Gavioli; Flavio Kapczinski; João Quevedo

Book ID: 111316468
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 167 KB
Volume: 103
Category: Article
ISSN: 1742-7835
DOI: 10.1111/j.1742-7843.2008.00210.x

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## Abstract Escitalopram (ES‐CIT) is a widely used, highly specific antidepressant. Until now there has been very little evidence on how this drug under pathological conditions affects an important feature within the pathophysiology of stress‐related disorders such as depression: the endogenous neu