Chronic administration of electroconvulsive shock and norepinephrine metabolism in the rat brain

✍ Scribed by W. Ladisich; N. Steinhauff; N. Matussek

• Publisher: Springer
• Year: 1969
• Tongue: English
• Weight: 469 KB
• Volume: 15
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00401684

✦ Synopsis

The chronic administration of ECS leads to a decrease of H3-1NE in all parts of the brain, and an increase in dihydroxymandelic acid, dihydroxy-13henylglykol, methoxy-hydroxymandelic acid, and methoxy-hydroxy13henylglykol. In the hy13othalamus and the cerebellum there is also an increase in normetane-13hrine, which is not observable in the other parts of the brain.

Uptake experiments in vitro showed a lower uptake of Ha-I~E in brain homogenates of ECS animals.

ECS in combination with DMY-treatment did not increase the NM-values whereas combination of ECS with lithium led to an increase of DH compounds and a corresponding decrease of NM.