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Chromosome breakage in lymphocytes from members of cancer families showing autosomal dominant inheritance

✍ Scribed by M. N. Khouzam; K. Tsioupra; J. D. A. Delhanty


Book ID
115090062
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
386 KB
Volume
38
Category
Article
ISSN
0009-9163

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## Abstract It has been suggested that common fragile sites (cFSs) are related to cancer development. This appears to be the case for FRA3B and FRA16D, localized in two tumor‐suppressor genes (__FHIT__ and __WWOX__, respectively) that are altered by deletions or loss of heterozygosity (LOH) in many