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Chromosome assignments of the human TNF p55 and p75 receptor genes

✍ Scribed by Brownell, Elise ;Ranges, G. E. ;Sarr, T. ;Fiorentino, L. ;Godfrey, M. ;Pekar, S. ;Hart, J. ;Kamarck, M. ;Rae, P. M. M. ;Ruddle, F. H. ;Bayney, R.

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 238 KB
Volume: 262
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402620314

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✦ Synopsis

Abstract

At least two different receptor molecules have been described that are capable of binding tumor necrosis factor alpha, a cytokine that plays an important role in inflammation and antitumor activity. Comparative analyses at the nucleotide sequence level suggest that these receptors are members of a newly defined protein family that also includes human and rat nerve growth factor receptors. In this study, we determine the chromosome assignments of the human TNF alpha receptor genes, one of which may have evolved as part of a conserved Hox locus‐containing chromosome segment. © 1992 Wiley‐Liss, Inc.

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