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Chromosome analysis of 20 breast carcinomas: Cytogenetic multiclonality and karyotypic-pathologic correlations

✍ Scribed by Nikos Pandis; Dr. Sverre Heim; Georgia Bardi; Ingrid Idvall; Nils Mandahl; Felix Mitelman

Book ID
102845444
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
526 KB
Volume
6
Category
Article
ISSN
1045-2257

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✦ Synopsis

Short-term cultures from 20 breast carcinomas were analyzed cytogenetically. A normal female chromosome complement was found in 4 cases. Clonal chromosome aberrations were detected in I 6 tumors. In I0 tumors, multiple cytogenetic clones were found; in 2 cancers the clones were related, reflecting clonal evolution, but in the remaining 8 tumors the clones were cytogenetically unrelated, indicating clonal heterogeneity in the origin of the tumor parenchyma. Correlation analysis between karyotypic and pathologic parameters indicated that cases with complex karyotypes and/or cytogenetically unrelated clones, when compared with cases with a single simple karyotypic abnormality, were generally of higher histologic malignancy grade, had more mitoses in the histologic sections, and also more often had carcinoma in situ lesions in the same breast. Genes Chrom

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