Loss of heterozygosity (LOH) is one of the most common genetic abnormalities in cancer. To define the role of LOH and chromosomal abnormalities at various stages of mouse mammary cancer progression, we analyzed the allelotypes and karyotypes of primary mammary tumors induced in CD2Fl mice by two bas
β¦ LIBER β¦
Chromosome analyses of human mammary epithelial cells at stages of chemical-induced transformation progression to immortality
β Scribed by Kirsten H. Walen; Martha R. Stampfer
- Book ID
- 119104086
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 907 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0165-4608
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Simian virus 40-immortalized human milk epithelial cells (HuMI) are anchorage dependent and nontumorigenic but can spontaneously progress to anchorage-independent and tumorigenic cells. To see whether HuMI cells can be transformed into anchorage-independent cells by chemical carcinogens, we treated