## Abstract ## BACKGROUND It has been reported that point mutations of the ras gene occur frequently in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). However, the prognostic significance of ras gene mutations in patients with these disorders has been a controversial issue. Altho
Chromosome analyses in patients with myelodysplastic syndromes: Correlation with bone marrow histopathology and prognostic significance
β Scribed by Werner, M. ;Maschek, H. ;Kaloutsi, V. ;Choritz, H. ;Georgii, A.
- Publisher
- Springer-Verlag
- Year
- 1992
- Tongue
- English
- Weight
- 704 KB
- Volume
- 421
- Category
- Article
- ISSN
- 0174-7398
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Thirty-eight consecutive patients with a FAB-classified primary myelodysplastic syndrome (MDS) were investigated for in vitro growth of colony-forming units for granulocyte-macrophage precursors (CFU-GM) and cytogenetic analysis of bone marrow cells. Abnormal CFU-GM growth was found in 30 patients (
## Abstract ## BACKGROUND: Lineage involvement and maturation arrest are considered to have prognostic significance in patients with myelodysplastic syndromes (MDS). However, although the prognostic value of neutropenia, thrombocytopenia, and monocytosis have been documented, little is known about