Chromosome analyses in man in the course of chemoprophylaxis against tuberculosis and of antituberculosis chemotherapy with isoniazid
✍ Scribed by M. Bauchinger; E. Gebhart; Ch. Fonatsch; E. Schmid; W. Müller; G. Obe; B. Beek; D. Göbel; K. L. Radenbach
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 520 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0340-6717
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✦ Synopsis
Cytogenetic analyses were carried out in lymphocytes of 37 persons before and during a primary chemoprophylaxis or a preventive chemotherapy with isoniazid as well as of 30 patients suffering from active pulmonary tuberculosis before and during a chemotherapy with isoniazid in combination with two other antimycobacterial drugs. The results of the four participating research groups consistently reveal no indication for a chromosome damaging activity of isoniazid, of its metabolites in the human organism and of the administered drug regimens.