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Chromosome Alignment and Transvection Are Antagonized by Condensin II

โœ Scribed by Hartl, Tom A. (author);Smith, Helen F. (author);Bosco, Giovanni (author)


Book ID
118128107
Publisher
American Association for the Advancement of Science
Year
2008
Tongue
English
Weight
366 KB
Volume
322
Category
Article
ISSN
0036-8075

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Merbarone is a catalytic inhibitor of topoisomerase II (topo II) that has been proposed to act primarily by blocking topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. In this study merbarone was used as a model compound to investigate the genotoxic effects of catalyt