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Chromosome abnormalities in squamous cell carcinoma of the urethra

✍ Scribed by Imad Fadl-Elmula; Ludmila Gorunova; Nils Mandahl; Peter Elfving; Sverre Heim

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 85 KB
Volume: 23
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199809)23:1<72::aid-gcc11>3.0.co;2-g

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✦ Synopsis

Cytogenetic analysis of short-term cultured cells from a urethral squamous cell carcinoma showed the tumor to have an abnormal, karyotypically complex near-diploid clone as well as its near-tetraploid duplicate. This is the first urethral carcinoma with chromosomal abnormalities to be reported. Chromosomes Y, 2, 3, 4, 6, 7, 8, 11, and 20 were all involved in numerical and/or structural rearrangements. Of particular interest was the fact that no rearrangements of chromosomes 9 and 17, both almost ubiquitously involved in transitional cell carcinoma of the urinary tract, were seen.

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