Chromosome abnormalities in non-small cell lung cancer pleural effusions: Cytogenetic indicators of disease subgroups
✍ Scribed by Robyn Lukeis; David Ball; Louis Irving; O. Margaret Garson; Dr. Suzanne Hasthorpe
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 649 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
✦ Synopsis
A cytogenetic study of pleural effusions (PE) containing metastatic or invasive tumor cells from I I patients with non-small cell lung cancer (NSCLC) (3 squamous cell carcinomas [SQC] and 8 adenocarcinomas [ADC] including I giant cell variant) was performed t o identify non-random chromosome abnormalities. Numerical abnormalities seen in 2 30% of cases included gain of chromosomes 7 and 20, and loss of chromosomes 4, 9, 10, I 3, IS, 16. 18, 19, 2 I, and 22. The most frequent structural abnormality involved rearrangement in I p with breakpoints clustering at I p 10-p I 3. Other recurrent breakpoint regions, seen in 2 30% of cases, occurred in chromosome regions 3p IO-p2 I, 3q I I -q25, 6p I I -p25, 6q I 3-q23, 7q I I -q36, 9q32-q34, I I p I Ip 13, I I q I 3-q24, I3pll4p and/or I5p, I7p and I9p, with, in particular, apparent loss of 6q2 I -q27, 3p2 I -p26, 7q2 I -q22, 9p22-p24 (shortest regions of common overlap) and I7p. There was also recurrent gain of I q23-q44,8q I 3-q24, and I I q I 3-q23. These abnormalities were not restricted t o a particular histological subtype, with the exception of + 8 and a breakpoint in 9q32-q34, which were seen only in ADC. The 9q32-q34 breakpoint observed in 4 ADC PE (including I giant cell variant) represents a new observation in NSCLC. These findings, when compared to those reported for primary NSCLC indicate cytogenetic differences between the two which may be associated with pleural invasion of NSCLC. Genes Chrorn Cancer