Cytogenetics provides important insights into the molecular pathogenesis of human cancers. Although extensive data exist on recurring cytogenetic abnormalities in hematologic cancers, data on individual solid tumor types remain limited. Previous studies of ovarian carcinoma indicated the presence of
Chromosome abnormalities in malignant melanoma:: clinical significance of nonrandom chromosome abnormalities in 206 cases
โ Scribed by Mark A Nelson; Michael D Radmacher; Richard Simon; Mikel Aickin; Jin-Ming Yang; Lita Panda; Julia Emerson; Denise Roe; Lawrence Adair; Floyd Thompson; Jerry Bangert; Stanley P.L Leong; Raymond Taetle; Sydney Salmon; Jeffrey Trent
- Book ID
- 114134931
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 456 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0165-4608
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In a large series of ovarian carcinomas from 244 patients, 134 cases had chromosome rearrangements. We showed before that the pattern of chromosome breakpoints involved 21 separate chromosome regions nonrandomly and, in 90% of cases with breaks, the breakpoints occurred within 13 commonly involved r
Chromosome 1 abnormalities are the most commonly detected aberrations in many cancers including malignant melanomas. Specific breakpoints are reported for malignant melanomas throughout the chromosome but especially at 1p36 and at several sites throughout 1p22-q21. In addition, partial deletions and